Anaspec/HCV NS3/4A蛋白酶基因型1b，重组/5µg/AS-61017-5
商品编号：
AS-61017-5
品牌：
Anaspec
市场价：
¥4940.00
美元价：
2470.00
产品分类：
稳转细胞株
公司分类：
Stable_cell_line
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | HCV NS3/4A protease genotype 1b, recombinant |
| Size | 5 µg |
| Catalog # | AS-61017-5 |
| US$ | $247 |
The NS3 protease of hepatitis C virus (HCV) is responsible for the cleavage at the NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites of the nonstructural protein. It is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy. Recombinant HCV NS3/4A protease is highly active and can be used with SensoLyte® 490 or 520 HCV Protease Assay Kits (Cat# 71126, 71145) to screen for anti-HCV protease drugs. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) Poster |
| Storage | Store at -80°C. Avoid multiple thaw-freeze cycles. |
| References | 1. R. Bartenschlager, R. et al. J.Virol. 67, 3835-3844 (1993).2. Eckart, MR. et al. Biochem.Biophys.Res.Commun. 192, 399-406 (1993).3. Landro, JA. et al. Biochemistry 36, 9340-9348 (1997).4. Kim, JL. et al. Cell 87, 343-355 (1996).5. Love, RA. et al. Cell 87, 331-342 (1996). |
| Product Citations | Ma, C. et al. (2009). HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives. J Pharm Pharmaceut Sci 12, 243.Phuong, DT. et al. (2009). Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother Res 23, 582.of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother. Res. 23, 582.Yu, X. (2009). Development of a cell-based hepatitis C virus (HCV) infection FRET assay for high throughput antiviral compound screening. Antimicrob Agents Chemo doi:10.1128/AAC.00495-09.Ma, C. et al. (2007). Triterpenes from Cynomorium songariciumanalysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating. J Nat Med 63, 9. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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