Anaspec/HIV - 1 Protease, recombinant/5 µg/AS-72028-5
商品编号:
AS-72028-5
品牌:
Anaspec
市场价:
¥7480.00
美元价:
3740.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | HIV - 1 Protease, recombinant |
Size | 5 µg |
Catalog # | AS-72028-5 |
US$ | $374 |
The 10-12 kD aspartic protease of human immunodeficiency virus-1 (HIV-1), active only when it forms a homodimer, is required for the post-translational cleavage of the precursor polyproteins, Gag, Gag-Pol, Pol, and Nef. Since the cleavages of precursors are essential for the maturation of HIV infectious particles, this protease is one of the key targets for developing anti-AIDS drugs.The recombinant HIV-1 protease (wild type, NCBI accession: NC_001802) contains the 99 amino acid sequence reported by Schneider, et al., with 6x His-tag at its C-terminal. 50-100 ng of HIV-1 protease is sufficient for FRET-based activity assays (SensoLyte® 490 and 520 HIV Protease Assay Kits, AnaSpec Cat#71127, 71147) in high throughput drug screening. | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | Store at -80°C.Avoid multiple thaw-freeze cycles. |
References | 1. Seelmeier, S. et al. Proc. Natl. Acad. Sci.USA. 85, 6612 (1988).2. Schneider, J. and SB. Kent, Cell 54, 363 (1988). |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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