| Product Name | SensoLyte ® 390 ACE2 Activity Assay Kit *Fluorimetric* |
| Size | 1 kit |
| Catalog # | AS-72086 |
| US$ | $480 |
ACE2 or ACEH, angiotensin-converting enzyme 2, a homolog of angiotensin-converting enzyme, is a novel zinc metallopeptidase with specificity, tissue distribution, and function distinct from those of ACE. ACE2 may play a unique role in the renin-angiotensin system and mediate cardiovascular and renal function. The SensoLyte® 390 ACE2 Activity Assay Kit provides a convenient assay for high throughput screening of ACE2 enzyme inhibitors and inducers using a Mc-Ala/Dnp fluorescence resonance energy transfer (FRET) peptide. In the FRET peptide, the fluorescence of Mc-Ala is quenched by Dnp. Upon cleavage into two separate fragments by ACE2, the fluorescence of Mc-Ala is recovered, and can be monitored at excitation/emission = 330/390 nm. This assay can detect the activity of subnanogram level of ACE2. Assays are performed in a convenient 96-well microplate format.Kit size: 100 assays COVID-19 Research Products | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| Product Citations | Liu, S. et al. (2014). Conversion of Aβ43 to Aβ40 by the successive action of angiotensin‐converting enzyme 2 and angiotensin‐converting enzyme. J Neurosci Res doi: 10.1002/jnr.23404.Raffai, G. et al. (2014). Angiotensin-(1-7) augments endothelium-dependent relaxations of porcine coronary arteries to bradykinin by inhibiting ACE1. J Cardiovasc Pharmacol 63, 453. doi: 10.1097/FJC.0000000000000069.Gao, H. et al. (2013). Gestational protein restriction increases angiotensin II production in rat lung. Biol Reprod 88, 3. doi: 10.1095/biolreprod.112.103770.Luhtala, S. et al. (2009). Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues. J. Ocul. Pharmacol. Ther. 25, 23. |
