Anaspec/SensoLyte®；490 MMP-12分析试剂盒*荧光法*/1试剂盒/AS-71137
市场价：
¥13260.00
美元价：
6630.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | SensoLyte ® 490 MMP - 12 Assay Kit *Fluorimetric* |
| Size | 1 kit |
| Catalog # | AS-71137 |
| US$ | $663 |
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. It has recently been shown to play a role in the pathogenesis of rheumatoid arthritis. The SensoLyte® 490 MMP-12 Assay Kit is a complete assay system designed to continuously analyze MMP-12 activity or to screen for MMP-12 inhibitors by using a fluorogenic MMP-12 substrate. The assays are performed in a convenient 96-well or 384-well microplate format. It provides speed, convenience and accuracy in analyzing MMP-12 and in screening MMP-12 inhibitors. Kit size: 500 assays | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| Product Citations | Song, Y. et al. (2013). Expression of matrix metalloproteinase-12 in aortic dissection. BMC Cardiovasc Disord 13, 34. doi:10.1186/1471-2261-13-34Chan, KH. et al. (2012). Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. Free Radical Res 46, 1123. doi: 10.3109/10715762.2012.692786Bogaert, P. et al. (2011). Inflammatory signatures for eosinophilic versus neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints. AJP-Lung Physiol doi: 10.1152/ajplung.00202.2010.Qu, P. et al. (2009). Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition. Cancer Res 69, 7252.Ma, X. et al. (2008). Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab 94, 298.Summer, R. et al. (2008).Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol 294, 1035.Demedts, IK. et al. (2006). Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 61, 196. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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