| Product Name | SensoLyte ®490 MMP - 9 Assay Kit *Fluorimetric* |
| Size | 1 kit |
| Catalog # | AS-71134 |
| US$ | $663 |
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-9 (gelatinase-B, collagenase-IV) is involved in quite a few diseases such as a cancer, angiogenesis, alopecia and metastasis. The SensoLyte® 490 MMP-9 Assay Kit is a complete assay system designed to continuously analyze MMP activity or to screen for MMP-9 inhibitors using a fluorogenic MMP-9 substrate. The assays are performed in a convenient 96-well or 384-well microplate format. The kit provides speed, convenience and accuracy in MMP-9 analysis.Members of the MMP family have poor substrate sequence specificity, making it difficult to use a peptide substrate alone to differentiate the activity of a particular MMP from other MMPs. If several MMPs are coexisting in your samples and you would like to specifically measure MMP-9 activity, please choose the SensoLyte® Plus MMP-9 Assay Kit, Cat# 72017. Kit size: 500 assays | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| Product Citations | Won, S. et al. (2013). Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGFMMP pathway. J Cerebral Blood Flow Metabolism. doi: 10.1038/jcbfm.2013.163.Mei, ML. et al. (2012). The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases. Dental Mat 28, 903.Djouad, F. et al. (2009). ERK1/2 Activation Induced by Inflammatory Cytokines Compromises Effective Host Tissue Integration of Engineered Cartilage. Tissue Eng Part A 15, 2825.Oh, JH. et al. (2009). Syndecan-1 enhances the endometrial cancer invasion by modulating matrix metalloproteinase-9 expression through nuclear factor kappaB. Gynecol Oncol 114, 509.Lin, C. et al. (2008). Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma. Carcinogenesis 29, 1807. |
