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Anaspec/SensoLyte ® Plus 520 MMP - 1 Assay Kit *Fluorimetric and Enhanced Selectivity*/1 kit/AS-72012
Anaspec/SensoLyte ® Plus 520 MMP - 1 Assay Kit *Fluorimetric and Enhanced Selectivity*/1 kit/AS-72012
市场价：
¥12020.00
美元价：
6010.00
产品分类：
恒温箱/烘箱
公司分类：
Thermostat
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | SensoLyte ® Plus 520 MMP - 1 Assay Kit*Fluorimetric and Enhanced Selectivity* |
| Size | 1 kit |
| Catalog # | AS-72012 |
| US$ | $601 |
The SensoLyte® Plus 520 MMP-1 Assay Kit is designed for specifically detecting MMP-1 activity in biological samples which may contain multiple MMPs, such as culture medium, serum, plasma, synovial fluid, and tissue homogenate. A specific anti-MMP-1 monoclonal antibody is used in combination with an MMP fluorogenic substrate, 5-FAM/QXL®520 FRET peptide. The fluorescence signal is monitored at Ex/Em=490 nm/520 nm upon MMP-1-induced cleavage of the FRET substrate. Ample materials are provided to perform 96 assays in a 96-well format. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) Poster |
| References | Jian J, Pelle E, Yang Q, Pernodet N, Maes D, Huang X. Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-? and ERK activation. Exp Dermatol. 2011 Mar; 20(3):249-54. PMID:20701626 |
| Product Citations | Carrizzo, A. et al. (2015). Pentraxin 3 induces vascular endothelial dysfunction through a P-selectin/Matrix Metalloproteinase-1 pathway. Circulation 131, 1495. doi: 10.1161/CIRCULATIONAHA.114.014822.Atay, S. et al. (2014). Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. PNAS 111, 711. doi: 10.1073/pnas.1310501111.Halvorsen, B. et al. (2014). Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells. Cardiovasc Res 102, 148. doi: 10.1093/cvr/cvu036.Mogami, H. et al. (2014). Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289, 13295. doi: 10.1074/jbc.M114.550541.Ozeki, N. et al. (2014). IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells. Exp Cell Res 323, 165.Mogami, H. et al. (2013) Fetal fibronectin signaling induces Matrix Metalloproteases and Cyclooxygenase-2(COX-2) in amnion cells and preterm birth in mice JBC 2883,1953 doi:10.1074/jbc.M112.424366Bogatkevich, GS. et al. (2012). The PPARγ agonist Rosiglitazone is antifibrotic for scleroderma lung fibroblasts: mechanisms of action and differential racial effects. Pulmonary Med doi:10.1155/2012/545172Leong, D. et al. (2011). Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J 25, 182.Park, C. et al. (2011). Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts. J Dermatol Sc 64, 134.Handy, J. et al. (2010). Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem 110, 1195.Cowan, RW. et al. (2009). Collagenase expression and activity in the stromal cells from giant cell tumour of bone. Bone 44, 865.Jian, J. et al. (2011). Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-α and ERK activation. Exp Dermatol 20, 249.Moor, A. et al. (2009). Proteolytic activity in wound fluids and tissues derived from chronic venous leg ulcers. Wound Repair Regen 17, 832.Shi, Z-D. et al. (2009). Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Am J Physiol Heart Circ Physiol 10.1152/ajpheart.00369.2009.Qazi, H. et al. (2011). Fluid shear stress regulates the invasive potential of glioma cells via modulation of migatory activity and matrix metalloproteinase expression. PLoS One 6, e20348. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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