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当前位置: 首页 > 产品中心 > Sensiscript_RT_Kit > Anaspec/攻击ᵀᴹ β - 淀粉样蛋白(1-40),人/0.25毫克净肽/AS-72215
商品详细Anaspec/攻击ᵀᴹ β - 淀粉样蛋白(1-40),人/0.25毫克净肽/AS-72215
Anaspec/攻击ᵀᴹ  β - 淀粉样蛋白(1-40),人/0.25毫克净肽/AS-72215
Anaspec/攻击ᵀᴹ β - 淀粉样蛋白(1-40),人/0.25毫克净肽/AS-72215
商品编号: AS-72215
品牌: Anaspec
市场价: ¥5420.00
美元价: 2710.00
产地: 美国(厂家直采)
公司:
产品分类: 逆转录试剂盒
公司分类: Sensiscript_RT_Kit
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionSequence(One-Letter Code)
Product NameAggreSureᵀᴹβ - Amyloid (1 - 40), humanDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Size0.25 mg NET peptide
Catalog #AS-72215
US$$271
Purity>95%

AggreSure™ beta-Amyloid (1-40) peptide is pretreated and tested for aggregation using SensoLyte® ThT Aβ40 Aggregation kit (Cat# 72213). Aggregation is guaranteed.

AS-72215 fig. 1

Figure 1. An increase of fluorescence signal is correlated with an increase of Aβ40 fibril formation. Phenol Red, 0-Vanillin, Dopamine, and Tannic Acid were added at 50 μM final concentration to inhibit Aβ40 aggregation. Fluorescence signal was monitored at Ex/Em= 440/484 nm every 5 minutes at 37ºC with 15 seconds shaking between reads (SpectraMax M5efluorimeter, Molecular Devices).
Detailed InformationDatasheet
Material Safety Data Sheets (MSDS)
Storage–20°C
Molecular Weight4329.9
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence(Three-Letter Code)H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH
Product CitationsManeshi, MM. et al. (2018). Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1. Sci Rep 8(1):14267. doi: 10.1038/s41598-018-32572-2.Hartz. AM, et al. (2016). Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway. J Neurosci. 36(6):1930-41. doi:10.1523/JNEUROSCI.0350-15.2016.Debner EK & King JM. (2016). Effects of Melatonin and Beta-Amyloid on Mitochondrial Function in a Model of Aging Mouse Astrocytes. The FASEB J 30(1_supplement):702-1.
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。