Anapec/β-淀粉样蛋白（25-35），人，小鼠/大鼠/5 mg/AS-24228
市场价：
¥3980.00
美元价：
1990.00
产品分类：
上样缓冲液
公司分类：
DNA_buffer_solution
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Beta - Amyloid (25 - 35), Human, mouse/ratGSNKGAIIGLM |
| Size | 5 mg |
| Catalog # | AS-24228 |
| US$ | $199 |
| Purity | % Peak Area By HPLC ≥ 95% |
Aß (25-35) is the main factor responsible for Aß neurotoxic effects. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Carvalho, K. et al. Braz. J. Med. Biol. Res. 3, 1153 (1997). |
| Molecular Weight | 1060.3 |
| GSNKGAIIGLM | |
| Sequence(Three-Letter Code) | H - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - OH |
| Product Citations | Hung, SY. et al. (2015). LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacol doi:10.1016/j.neuropharm.2015.02.003.Qu, J. et al. (2011)S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide. PNAS 108, 14330 (2011). doi: 10.1073/pnas.1105172108Morte, B. et al. (2011). Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells. Neurochem Int doi:10.1016/j.neuint.2011.01.019.Ravindran, C. et al. (2010). CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol 260, 113.Huang, W-C. et al. (2009). Enlargement of Aβ aggregates through chemokine-dependent microglial clustering. Neurosci. Res. 63, 280.Wang, HY. et al. (2009). Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer"s Disease brain. J Neurosci 29, 10961.Seyb, K. et al. (2008). Identification of small molecule inhibitors of β-amyloid cytotoxicity through a cell-based high-throughput screening platform. J Biomol Screen 13, 870.Sun, K. et al. (2008). Novel Genetic Tools Reveal Cdk5s Major Role in Golgi Fragmentation in Alzheimers Disease. Mol Biol Cell 19, 3052.Tateno, M. et al. (2008). Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. Pro Neuro-Pyschopharmacol Biol Pysch 32, 1704.Hashioka, S. et al. (2007). Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation. Free Radical Bio. Med. 42, 945.Martínez, T. and A. Pascual (2007). Gene expression profile in β-amyloid-treated SH-SY5Y neuroblastoma cells.Brain Res. Bull. 72, 225.Nelson, TJ. and DL. Alkon (2007). Protection againstβ-Amyloid-induced Apoptosis by Peptides Interacting withβ-Amyloid. J. Biol. Chem. 282, 31238.Pu, F. et al. (2005). Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons and spatial memory impairment induced by scopolamine in an eight-arm radial maze. J. Health Sci. 51, 636.Egashira, N. et al. (2002). Hypoxia enhances β-amyloid-induced apoptosis in rat cultured hippocampal neurons. Japanese J. Pharmacol. 90, 321.Kawahara, M. and Y. Kuroda (2001). Intracellular Calcium Changes in Neuronal Cells Induced by Alzheimer"s ß-Amyloid Protein Are Blocked by Estradiol and Cholesterol. Cell. Mol. Neurobio. 21, 1.Yatin, S. et al. (1999). Alzheimer"s amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett 263, 17.Yatin, SM. et al. (1998). Temporal relations among amyloid β-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses. J. Mol. Neurosci. 11, 183. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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