Anaspec/β-淀粉样蛋白(1-42),5-TAMRA标记,人/0.1 mg/AS-60476
市场价:
¥5200.00
美元价:
2600.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | Beta - Amyloid (1 - 42), 5 - TAMRA - labeled, Human5 - TAMRA - DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
Size | 0.1 mg |
Catalog # | AS-60476 |
US$ | $260 |
Purity | % Peak Area By HPLC ≥ 95% |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | -20°C |
Molecular Weight | 4926.6 |
5-TAMRA-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA | |
Sequence(Three-Letter Code) | 5 - TAMRA - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH |
Spectral Properties | Abs/Em = 544/572 nm |
Solvent System | N/A |
Product Citations | Ahn, HJ. et al. (2014). A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimers disease mice. J Exp Med 211, 1049. doi: 10.1084/jem.20131751.Domert, J. et al. (2014). Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance. Neurobiol Disease 65, 82. doi: 10.1016/j.nbd.2013.12.019.Zhang, YH. et al. (2014). K114 Inhibits A-beta Aggregation and Inflammation In Vitro and In Vivo in AD/Tg Mice. Curr Alzheimer Res 11, 299. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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