Anaspec/β-淀粉样蛋白（1-42），人类/0.5 mg/AS-24224
市场价：
¥3160.00
美元价：
1580.00
产品分类：
液闪仪
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Beta - Amyloid (1 - 42), HumanDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Size | 0.5 mg |
| Catalog # | AS-24224 |
| US$ | $158 |
| Purity | % Peak Area By HPLC ≥ 95% |
Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimers disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimers disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. Solvent Information | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Nagele, R. et al. Neurosci. 110, 199 (2002); Garzon-Rodriguez, W. et al. J. Biol. Chem. 272, 21037 (1997). |
| Molecular Weight | 4514.1 |
| DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA | |
| Sequence(Three-Letter Code) | H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH |
| Product Citations | Bell-Temin, H. et al (2015). Novel molecular insights into classical and alternative activation states of microglia as revealed by stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics MCP doi: 10.1074/mcp.M115.053926.Mandler, M. et al. (2015). Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines PLoS One doi:10.1371/journal.pone.0115237.Hung, SY. et al. (2015). LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacol doi:10.1016/j.neuropharm.2015.02.003.Rapsinski, GJ. et al. (2015). Toll-Like Receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, Curli. Infect immun 83, 693. doi: 10.1128/IAI.02370-14.Jacobsen, H. et al. (2014). Combined treatment with a BACE inhibitor and anti-Aβ antibody Gantenerumab enhances amyloid reduction in APPLondon mice. J Neurosci 34, 11621. doi: 10.1523/JNEUROSCI.1405-14.2014. Zhang, QG. et al. (2013). Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 136, 1432. doi: 10.1093/brain/awt046.Chen, J. & K. Herrup (2012). Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. Plos One doi: 10.1371/journal.pone.0033177Ohta, H. et al. (2012). Effects of NK-4 in a transgenic mouse model of alzheimer"s disease. Plos One doi:10.1371/journal.pone.0030007.Orlando, RA. et al. (2012). A chemical analog of Curcumin as an improved inhibitor of amyloid Abeta oligomerization. Plos One doi: 10.1371/journal.pone.0031869.Takata, K. et al. (2012). Microglial amyloid-β1-40 phagocytosis dysfunction is caused by high-mobility group box protein-1: Implications for the pathological progression of Alzheimers Disease. Intl J Alz Dis doi:10.1155/2012/685739Davis, RC. et al. (2011). Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Mol Neurodegener 6, 10.Dillen, L. et al. (2011). A screening UHPLCMS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species. Bioanalysis 3, 45. doi: 10.4155/bio.10.163.Li, W. et al. (2011). Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein. Brain Res 10.1016/j.brainres.2011.02.078.Li, Y-P. et al. (2011). Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur J Med Chem 46, 1472. doi: 10.1016/j.ejmech.2011.02.005.Libeu, CP. et al. (2011). Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimer"s Dis 25, 547.Pandya, A. & JL. Yakel (2011). Allosteric modulator desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-Amyloid 142 peptide. J Mol Neurosci doi: 10.1007/s12031-011-9509-3.Qu, J. et al. (2011) S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide. PNAS 108, 14330 (2011). doi: 10.1073/pnas.1105172108.Wu, J. et al. (2011). Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo. Biochem Biophys Res Commun 408, 382. doi: 10.1016/j.bbrc.2011.04.013.Yin, F. et al. (2011). Silibinin: A novel inhibitor of Aβ aggregation. Neurochem Int 58, 399. doi: 10.1016/j.neuint.2010.12.017.Spuch, C. et al. (2010). A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer"s Disease. Neurotox Res 17, 421. doi: 10.1007/s12640-009-9121-2.Aksenov, MY. et al. (2010). HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures. Neurosci Lett 475, 174. doi:10.1016/j.neulet.2010.03.073.Van Helmond, Z. et al. (2010). Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer"s Disease. Brain Pathol 20, 787. doi: 10.1111/j.1750-3639.2010.00374.x.Nagano, T. et al. (2010). Prostaglandin E2 reduces amyloid β-induced phagocytosis in cultured rat microglia. Brain Res 1323, 11. doi: 10.1016/j.brainres.2010.01.086.Ravindran, C. et al. (2010). CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol 260, 113. doi: 10.1016/j.cellimm.2009.10.001.Ryan, D. et al. (2010). An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Meth 190, 171. doi: 10.1016/j.jneumeth.2010.05.001.Storace, D. et al. (2010). Elevation of β-amyloid 1-42 autoantibodies in the blood of amnestic patietns with mild cognitive impairment. Arch Neurol 67, 867. doi:10.1001/archneurol.2010.137.Tian, G. et al. (2010). Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer"s disease. J Neurochem 113, 978. doi: 10.1111/j.1471-4159.2010.06661.x.Tran, TT. et al. (2010). Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer"s disease. Hippocampus doi: 10.1002/hipo.20790.Vargas, T. et al. (2010). Gelsolin restores Aβ-induced alterations in choroid plexus epithelium. J Biomed Biotech 10.1155/2010/805405.Wang, Y. et al. (2010). Two-photon and time-resolved fluorescence conformational studies of aggregation in amyloid peptides. J Phys Chem B 114, 7112. doi: 10.1021/jp101496y.Wirths, O. et al. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimers disease cases. J Neural Transmission 117, 85. doi: 10.1007/s00702-009-0314-x.Arriagada, C. et al. (2009). Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Neuro Lett 470, 81. doi:10.1016/j.neulet.2009.12.062.Giliberto, L. et al. (2009). Mutant presenilin 1 increases the expression and activity of BACE1. J Biol Chem 284, 9027. doi: 10.1074/jbc.M805685200. Gu, Z. et al. (2009). β-Amyloid impairs AMPA receptor trafficking and function by reducing CA2+/calmodulin-dependent protein kinase II synaptic distribution. J Biol Chem 284, 10639. doi: 10.1074/jbc.M806508200.Guix, FX. et al. (2009). Amyloid-dependent triosphosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain 132, 1335. doi: 10.1093/brain/awp023.Li, M. et al. (2009). Amyloid Aβ interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier. J Immunol 182, 5778. doi: 10.4049/jimmunol.0803013 Zhao, L. et al. (2009). Macrophage-mediated degradation of Aβ-amyloid via an apolipoprotein E isoform-dependent mechanism. J Neurosci 29, 3603. doi: 10.1523/JNEUROSCI.5302-08.2009. Gevorkian, G. et al. (2008). Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B). Neurochem Int 52, 1030. doi:10.1016/j.neuint.2007.10.020.Jimenez, S. et al. (2008). Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer"s Disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci 28, 11650. doi: 10.1523/JNEUROSCI.3024-08.2008.Solorzano-Vargas, RS. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881. doi: doi:10.1016/j.molimm.2007.08.008.Watanabe, T. et al. (2008). Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats. J Pharmacol Sci 106, 84.Chafekar, SM. et al. (2007). Aβ 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signaling 9, 2245.Nelson, TJ. & DL. Alkon (2007). Protection against beta-amyloid induced apoptosis by peptides interacting with beta-amyloid. J Biol Chem 282, 31238. doi: 10.1074/jbc.M705558200. Bales, KR. et al. (2006). Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Aβ antibody. J Clin Invest 116, 825. doi:10.1172/JCI27120. Guo, J-P. et al. (2006). Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer"s disease. PNAS 103, 1953.Shaked, GM. et al. (2006). Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP597-624). FASEB J 20, 1254.doi: 10.1096/fj.05-5032fje.Osada, Y. et al. (2005). CLAC binds to amyloid β peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280, 8596. doi: 10.1074/jbc.M413340200.Piccini, A. et al. (2005). β-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem 280, 34186.Seidler, N. & TJ. Squire (2005). Aβ-polyacrolein aggregates: Novel mechanism of plastic formation in senile plaques. Biochem Biophys Res Communications 335, 501.Boyd-Kimball, D. et al. (2004). Role of phenylalanine 20 in Alzheimer"s amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity. Chem Res Toxicol 17, 1743.Legleiter, J. et al. (2004). Effect of different anti-Aβ antibodies on Aβ fibrillogenesis as assessed by atomic force microscopy. J Mol Biol 335, 997. doi:10.1016/j.jmb.2003.11.019.Bard, F. et al. (2003). Epitope and isotope specificities of antibodies to β-amyloid peptide for protection against Alzheimer"s disease-like neuropathology. PNAS 100, 2023. doi:10.1073/pnas.0436286100.Takata, K. et al. (2003). Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis. Biochem Biophys Res Commun 301, 699. doi:10.1016/S0006-291X(03)00024-X.Uryu, S. et al. (2003). β-amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Biochem Biophys Res Commun 303, 302. doi:10.1016/S0006-291X(03)00334-6.Arispe, N. & M. Doh (2002). Plasma membrane cholesterol controls the cytotoxicity of Alzheimer"s disease AβP (1-40) and (1-42) peptides. FASEB J 16, 1526. doi: 10.1096/fj.02-0829com. Kanski, J. et al. (2002). The hydrophobic environment of Met35 of Alzheimer"s Aβ(1-42) is important for the neurotoxic and oxidative properties of the peptides. Neurotox Res 10.1080/10298420290023945.Barger, SW. & AS. Basile (2001). Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem 76, 846. doi: 10.1046/j.1471-4159.2001.00075.x.Yao, Z-X. et al. (2001). The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cel death by inhibiting the formation of β-derived diffusible neurotoxic ligands. Brain Res 889, 181. doi: 10.1016/S0006-8993(00)03131-0.Yatin, SM. et al. (2000). Vitamin E prevents Alzheimer"s amyloid β-peptide (1-42)-induced neuronal protein oxidation and reactive oxygen species production. J Alzheimer"s Dis 2, 123.Yao, Z-X. et al. (1999). Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death. Brain Res 847, 203. doi: doi:10.1016/S0006-8993(99)02047-8.Yatin, SM. et al. (1999). Alzheimer"s amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett 263, 17. doi: 10.1016/S0304-3940(99)00101-9.Bradt, BM. et al. (1998). Complement-dependent proinflammatory properties of the Alzheimer"s disease β-peptide. J Exp Med 188, 431. doi: 10.1084/jem.188.3.431. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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