Anaspec/β-淀粉样蛋白（1-40）-Lys（LC-生物素）-NH2，FAM-标记，人类/0.1 mg/AS-61962-01
商品编号：
AS-61962-01
品牌：
Anaspec
市场价：
¥4980.00
美元价：
2490.00
产品分类：
抗绵羊
公司分类：
Anti_sheep
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Beta - Amyloid (1 - 40) - Lys(LC - biotin) - NH2, FAM - labeled, HumanFAβB |
| Size | 0.1 mg |
| Catalog # | AS-61962-01 |
| US$ | $249 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a 5-FAM labeled ß-?Amyloid (1-40). This amidated peptide is also biotinylated on the lysine side chain with 6-aminohexanoate (LC) as a spacer, Ex/Em=490 nm/ 520 nm. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| Molecular Weight | 5154.9 |
| 5-FAM-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-K(LC-BIOTIN)-NH2 | |
| Sequence(Three-Letter Code) | 5 - FAM - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Lys(LC - Biotin) - NH2 |
| Product Citations | Powell, LR. et al. (2012). Probing the efficacy of peptide-based inhibitors against acid-and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopy. Biophys Chem 160, 12. doi: doi:10.1016/j.bpc.2011.08.006.Ralat, LA. et al. (2009). Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation. J Biol Chem 284, 34005. doi: 10.1074/jbc.M109.030627.Dukes, KD. et al. (2008). Monitoring the earliest amyloid-beta oligomers via quantized photobleaching of dye-labeled peptides. Anal. Biochem. 382, 29. doi: 10.1016/j.ab.2008.07.011.Im, H. (2007). Structure of substrate-free human Insulin-degrading Enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J. Biol. Chem. 282, 25453. doi: 10.1074/jbc.M701590200. Sun, ZX. et al. (2005). Cholesterol depletion inhibits the degradation of amyloid β-peptide in rat pheochromocytoma (PC12) cells. Neurosci. Lett. 391, 71. doi: 10.1016/j.neulet.2005.08.034. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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