Anaspec/Beta - Amyloid (1 - 40), Human/0.5 mg/AS-24235
市场价：
¥2780.00
美元价：
1390.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Beta - Amyloid (1 - 40), HumanDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
| Size | 0.5 mg |
| Catalog # | AS-24235 |
| US$ | $139 |
| Purity | % Peak Area By HPLC ≥ 95% |
Aß (1-40) together with Aß (1-42) are two major C-terminal variants of the Aß protein constituting the majority of Aßs. These undergo post-secretory aggregation and deposition in the Alzheimers disease brain.Electron microscopy of b-amyloid (1-40) stained with Thioflavin T (data generated by an AnaSpec scientist). Solvent Information | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Masters, CL. et al. Proc. Natl. Acad. Sci. USA 82, 4245 (1985); Yankner, BA. Neuron 16, 921 (1996); Geula, C. et al. Nat. Med. 4, 827 (1998); Shin, R. et al. J. Neurosci.17, 8187 (1997). |
| Molecular Weight | 4329.9 |
| DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV | |
| Sequence(Three-Letter Code) | H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH |
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Gelsolin restores Aβ-induced alterations in choroid plexus epithelium. J Biomed Biotech 10.1155/2010/805405.Davis, TJ. et al. (2009). Comparative study of inhibition at multiple stages of amyloid-β self-assembly provides mechanisitic insight. Mol Pharmacol 76, 405. doi: 10.1124/mol.109.055301.Lin, MS. et al. (2009). Dynamic fluorescence imaging analysis to investigate the cholesterol recruitment in lipid monolayer during the interaction between β-amyloid (140) and lipid monolayers. Colloids Surf B 74, 59. doi: 10.1016/j.colsurfb.2009.06.027.Liu, L. et al. (2009). Differential modification of Cys10 alters transthyretin"s effect on beta-amyloid aggregation and toxicity. PEDS 10.1093/protein/gzp025. doi: 10.1093/protein/gzp025.Muresan, V. et al. (2009). The cleavage products of amyloid-β precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J Neuro Sci 29, 3565. doi: 10.1523/JNEUROSCI.2558-08.2009.Andras, IE. et al. (2008). 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品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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