Anaspec/β-淀粉样蛋白(1-11),人/1mg/AS-22819
市场价:
¥1460.00
美元价:
730.00
产品分类:
RNA干扰
公司分类:
RNA_interference
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | Beta - Amyloid (1 - 11), HumanDAEFRHDSGYE |
Size | 1 mg |
Catalog # | AS-22819 |
US$ | $73 |
Purity | % Peak Area By HPLC ≥ 95% |
Anionic interaction of Aß(1-11) with Factor XII is suspected to cause the massive activation of the C4 (Complement 4) system in cerebrospinal fluid of Alzheimers disease patients. | |
Detailed Information | Material Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Ref: Chauhan, V. et al. J. Alzheimers Dis. 7, 37 (2005); Miller, D. et al. Biochem. 42, 11682 (2003); Bergamaschini, L. et al. Mech. Aging Dev. 122, 1971 (2001); Webster, S. et al. Am. J. Pathol. 150, 1531 (1997). |
Molecular Weight | 1325.3 |
DAEFRHDSGYE | |
Sequence(Three-Letter Code) | H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - OH |
Product Citations | Fukuyama, Y. et al. (2012). Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis. Anal Chem 84, 4237.Ved Chauhan et al. J Alzheimer"s Dis 7, 1 (2005)McLachlin, D. et al. (2003). Improved β-Elimination-Based Affinity Purification Strategy for Enrichment of Phosphopeptides. Anal Chem 75, 6826. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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