Anaspec/BSB/5 mg/AS-88300
市场价：
¥2500.00
美元价：
1250.00
产品分类：
稳转细胞株
公司分类：
Stable_cell_line
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | BSB[(trans,trans) - 1 - Bromo - 2,5 - bis - (3 - hydroxycarbonyl - 4 - hydroxy)styrylbenzene] |
| Size | 5 mg |
| Catalog # | AS-88300 |
| US$ | $125 |
BSB, derived from the structure of Congo Red, is shown to bind to a wide range of amyloid inclusions in situ. More importantly it is also used to label brain amyloids in live animals. BSB recognizes amyloid lesions, and has distinctive properties which allow the quantitative monitoring of the formation of amyloid fibrils assembled from the Ab peptide, a-synuclein and tau. It is a cell-permeable fluorescent probe that specifically binds to and labels intracellular b-amyloid aggregates both in vitro (Ki = 400 nM) and in vivo. It is also used as an antemortem diagnostic tool for animal models of Alzheimers disease.
| |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C desiccated and protected from light |
| References | 1. Crystal AS, et al. (2003).J Neurochem 86, 1359-68. 2. Kung MP, et al. (2002).J Mol Neurosci 19, 7-10. |
| Molecular Weight | 481.292 |
| Molecular Formula | C24H17BrO6 |
| Spectral Properties | Abs/Em = 340/520 nm |
| Solvent System | DMSO |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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