Anaspec/CKS-17（二聚体），MN10021/1 mg/AS-64578
市场价：
¥3400.00
美元价：
1700.00
产品分类：
克隆基因
公司分类：
Cloned_Genes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | CKS - 17 (dimer), MN10021LQNRRGLDLLFLKEGGLC (dimer) |
| Size | 1 mg |
| Catalog # | AS-64578 |
| US$ | $170 |
A dimer of CKS-17 has a natural occurring cysteine at the carboxyl terminus (where it occurs in the retroviral peptides on which CKS-17 is based) and dimerization is accomplished by cysteine-disulfide linkage. CKS-17 is a synthetic retroviral envelope heptadecapeptide corresponding to a region highly conserved in retroviral transmembrane proteins such as pl5E. The CKS-17 peptide has been previously shown to inhibit monocyte superoxide production, natural killer cell activity, polyclonal B-cell activation, and monocyte-mediated killing by inactivation of interleukin-1. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Nelson, M. et al. Cancer Immunol Immunother 30, 113 (1989). |
| Molecular Weight | 4088.8 |
| LQNRRGLDLLFLKEGGLC (dimer) | |
| Sequence(Three-Letter Code) | H - Leu - Gln - Asn - Arg - Arg - Gly - Leu - Asp - Leu - Leu - Phe - Leu - Lys - Glu - Gly - Gly - Leu - Cys - OH |
| Product Citations | Tolstrup, M et al (2013). Anti-inflammatory effect of a retrovirus-derived immunosuppressive peptide in mouse models.BMC Immuno 14:51. doi:10.1186/1471-2172-14-51 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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