Anaspec/Pannexin - 1 (Panx1), Mimetic Blocking Peptide/1 mg/AS-61911
市场价：
¥1460.00
美元价：
730.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Pannexin - 1 (Panx1), Mimetic Blocking PeptideWRQAAFVDSY |
| Size | 1 mg |
| Catalog # | AS-61911 |
| US$ | $73 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1? (IL-1?) in response to P2X7R activation. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Pelegrin, P. et al. EMBO.J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007). |
| Molecular Weight | 1242.4 |
| WRQAAFVDSY | |
| Sequence(Three-Letter Code) | H - Trp - Arg - Gln - Ala - Ala - Phe - Val - Asp - Ser - Tyr - OH |
| Product Citations | Karpuk, N. et al. (2011). Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity. J Neurosci 31, 414. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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