Anaspec/JAG-1（188-204），JAG-1（188-204），Notch配体，DSL肽/1mg/AS-61298
市场价：
¥3240.00
美元价：
1620.00
产品分类：
冻干机
公司分类：
Freeze_dryer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | JAG - 1 (188 - 204), Jagged - 1 (188 - 204), Notch Ligand, DSL PeptideCDDYYYGFGCNKFCRPR |
| Size | 1 mg |
| Catalog # | AS-61298 |
| US$ | $162 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-κB activation. Related Product: Jagged-1, scrambled, cat# 64239 | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Nickoloff, B. et al. Cell Death Different. 9, 842 (2002). |
| Molecular Weight | 2107.4 |
| CDDYYYGFGCNKFCRPR | |
| Sequence(Three-Letter Code) | H - Cys - Asp - Asp - Tyr - Tyr - Tyr - Gly - Phe - Gly - Cys - Asn - Lys - Phe - Cys - Arg - Pro - Arg - OH |
| Product Citations | Yamamoto, Y. et al. (2016).Mutational spectrum of Barrett"s stem cells suggests paths to initiation of a precancerous lesion.Nat Commun7, 10380.doi: 10.1038/ncomms10380. Xie, K. et al. (2015). Notch signaling activation is critical to the development of neuropathic pain. BMC Anesthesiol 15, 41. doi: 10.1186/s12871-015-0021-0.Wang, X. et al. (2015). Cloning and Variation of Ground State Intestinal Stem Cells Nature 522(7555) 173-178.doi:10.1038/nature14484Yamamura, H. et al. (2014).Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2entry in human pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol 306, C871. doi: 10.1152/ajpcell.00221.2013.Cioff, S. et al. (2013). Tbx1 regulates brain vascularization. Hum Mol Genet doi: 10.1093/hmg/ddt400. Onuma, K. et al. (2013). Genetic reconstitution of tumorigenesis in primary intestinal cells. PNAS 110, 11127.doi: 10.1073/pnas.1221926110.Wang, F. et al. (2013). Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay. Gastroenterol 145, 383. doi: 10.1053/j.gastro.2013.04.050. VanDussen, KL. et al. (2012). Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139, 488. doi: 10.1242/dev.070763.Van Landeghem, L. et al. (2012). Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 302, G1111. doi: 10.1152/ajpgi.00519.2011.Fox, RG. et al. (2012). Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol 302, G914. doi: 10.1152/ajpgi.00402.2011.Ramalingam, S. et al. (2012). Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. Am J Physiol Gastrointest Liver Physiol 302, G10. doi: 10.1152/ajpgi.00277.2011.Yao, H. et al. (2011). Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: Implications for HIV-associated neurological disorders. J Neurosci 31, 12449. doi: 10.1523/JNEUROSCI.2330-11.2011.Gracz, AD. et al. (2010). Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol 298, G590. doi: 10.1152/ajpgi.00470.2009.Ma, X-B. et al. (2009). Expression and role of Notch signalling in the regeneration of rat tracheal epithelium. Cell Proliferation 42, 15. Sainson, RCA. et al (2005). Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB Journal 19, 1027. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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