Anaspec/pro - NPY peptide (34 - 43), human/0.1 mg/AS-65602
市场价：
¥4100.00
美元价：
2050.00
产品分类：
测序酶
公司分类：
Sequencing_enzyme
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | pro - NPY peptide (34-43), humanQXL®520 -RQRYGKRSSP -K(5 - FAM) - NH2 |
| Size | 0.1 mg |
| Catalog # | AS-65602 |
| US$ | $205 |
| Purity | >95% |
This peptide corresponds to host derived pro-NPY sequence with a cathepsin cleavage site. Host proteases, such as cathepsin L are involved in the processing and biosynthesis of neuropeptides including pro-NPY. In viral propagation, cathepsin mediated cleavage of viral proteins is necessary for cell entry, thereby affecting the host protein derived pro-NPY.The peptide is labeled with QXL®520 and 5-FAM as FRET pair and thus can serve as a substrate for investigation enzyme cleavage.Neuropeptide Y (NPY) functions as a peptide neurotransmitter and as a neuroendocrine hormone. The active NPY peptide is generated in secretory vesicles by proteolytic processing of pro-NPY. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20 °C |
| References | 1. Elshabrawy HA, ET AL. Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. J Virol. 2014;88(8):43534365. 2. Funkelstein L, et al. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J. Neurochem. 2008; 106:384391. |
| QXL®520- RQRYGKRSSP- K(5-FAM)-NH2 | |
| Sequence(Three-Letter Code) | QXL®520 -Arg - Gln - Arg - Tyr - Gly - Lys - Arg - Ser - Ser - Pro - Lys(5 - FAM) - NH2 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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