Anaspec/Prosaptide TX14（A）/1 mg/AS-60248-1
商品编号：
AS-60248-1
品牌：
Anaspec
市场价：
¥2040.00
美元价：
1020.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Prosaptide TX14(A)TaLIDNNATEEILY |
| Size | 1 mg |
| Catalog # | AS-60248-1 |
| US$ | $102 |
| Purity | % Peak Area By HPLC ≥ 95% |
This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named prosaptides. Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Campana, M. et al. FASEB J. 12, 307 (1998); Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997); Taylor, E. et al. Pharmacol. 295, 190 (2000); Calcutt, NA. et al. Anesthesiology 93, 1271 (2000). |
| Molecular Weight | 1579.7 |
| TaLIDNNATEEILY | |
| Sequence(Three-Letter Code) | H - Thr - D - Ala - Leu - Ile - Asp - Asn - Asn - Ala - Thr - Glu - Glu - Ile - Leu - Tyr - OH |
| Product Citations | Meyer, R. et al. (2013). GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PNAS 110, 9529.doi: 10.1073/pnas.1219004110.Calcutt, NA. et al. (2004). Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiol 93, 1271 (2000).Otero, D. et al. (1999). Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide TX14(A). Neurosci Lett 270, 29.Campana, WM. et al. (1998). Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J.12, 307. Hiraiwa, M. et al. (1997). Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. PNAS 94, 4778. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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