Anaspec/IRBP,光感受器间维甲酸结合蛋白片段/5 mg/AS-60183-5
商品编号:
AS-60183-5
品牌:
Anaspec
市场价:
¥9880.00
美元价:
4940.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | IRBP, Interphotoreceptor Retinoid Binding Protein FragmentSGIPYIISYLHPGNTILHVD |
Size | 5 mg |
Catalog # | AS-60183-5 |
US$ | $494 |
Purity | % Peak Area By HPLC ≥ 95% |
This 20-residue peptide, a major pathogenic T-cell epitope (161180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU). | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Ref: Sonoda, K. et al. J. Immunol. 171, 2652 (2003); Read, RW. and SR. Barnum, ARVO Meeting Abstracts 43, 2281 (2002); Silver, P. et al. Invest. Ophthal. Vis. Sci. 36, 946 (1995); Karabekian, Z. et al. Invest. Ophthalmol. Vis. Sci. 46, 3769 (2005). |
Molecular Weight | 2209.5 |
SGIPYIISYLHPGNTILHVD | |
Sequence(Three-Letter Code) | H - Ser - Gly - Ile - Pro - Tyr - Ile - Ile - Ser - Tyr - Leu - His - Pro - Gly - Asn - Thr - Ile - Leu - His - Val - Asp - OH |
Product Citations | Zhang, Z. et al. (2012). Low dose rapamycin exacerbates autoimmune experimental uveitis. Plos One doi:10.1371/journal.pone.0036589An, F. et al. Invest Ophthalmol Vis Sci 50, 3778 (2009).Tan, Jung. et al. J Immunol 178, 5578 (2007).Pennesi, G. et al. J Clin Invest 111, 1171 (2003). |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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