Anaspec/Myristolated PKC Zeta，假底物拉链，炒制/1 mg/AS-63695
市场价：
¥2500.00
美元价：
1250.00
产品分类：
荧光计
公司分类：
Fluorometry
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Myristolated PKC Zeta, Pseudosubstrate ZIP, ScrambledMyristoyl - RLYRKRIWRSAGR |
| Size | 1 mg |
| Catalog # | AS-63695 |
| US$ | $125 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a myristoylated peptide used as a control for the pseudosubstrate PKC Zeta. Scrambled ZIP has been used as a control for ZIP as it has identical amino acids as that of ZIP but in an altered sequence that decreases its efficacy by 3- to 4-fold. It has been used in studies to compare the effectiveness or activity of the pseudosubstrate. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Yao Y. et al. Neuropharmacol, 64:37-44 (2013). 2, Dang P M-C. et al. J Immunol, 166(2):1206-1213 (2001) |
| Molecular Weight | 1928.5 |
| Myristoyl-RLYRKRIWRSAGR | |
| Sequence(Three-Letter Code) | Myristoyl - Arg - Leu - Tyr - Arg - Lys - Arg - Ile - Trp - Arg - Ser - Ala - Gly - Arg - OH |
| Product Citations | Bogard, A. S. et al. (2015). Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation. Mol Pharmcol doi: 10.1124/mol.115.099457. Deng, Z. et al. (2015). Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach. Neurobiol Learning Memory 118, 89.Kim, JV. et al. (2015). Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci 35, 6307. doi: 10.1523/JNEUROSCI.3481-14.2015.Tillu, DV. et al. (2015). Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state Short Title: PAR2 activation causes chronic pain. Pain doi: 10.1097/j.pain.0000000000000125.Yao, Y. et al. (2013). Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacol 64, 37.Pauli, WM. et al. (2012). Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. Learn Mem 19, 307. doi: 10.1101/lm.025148.111.Wu-Zhang, AX. et al. (2012). Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Its in Vitro Profile IMPLICATIONS FOR PKMζ AS A MEDIATOR OF MEMORY. J Biol Chem 287, 12879. doi: 10.1074/jbc.M112.357244.Hardt, O. et al. (2010). PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus. Hippocampus 20, 691. doi: 10.1002/hipo.20708.Migues, P. et al. (2010), PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci 13, 630. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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