Anaspec/肉豆蔻化PKC Zeta，假底物（ZIP）/1 mg/AS-63361
市场价：
¥2500.00
美元价：
1250.00
产品分类：
冻存试剂
公司分类：
Cryopreservation_reagent
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Myristolated PKC Zeta, Pseudosubstrate (ZIP)Myr - SIYRRGARRWRKL |
| Size | 1 mg |
| Catalog # | AS-63361 |
| US$ | $125 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a myristoylated PKCζ pseudosubstrate-derived ζ-inhibitory peptide (ZIP) found to inhibit an atypical type of Protein Kinase C ζ (zeta). It has been shown to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. The pseudosubstrate peptide has also been shown to be a competitive inhibitor of PKCζ in neurons. This peptide was also used to demonstrate thatPKC ζ is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Bogard AS. and Tavalin JS. Mol Pharmacol, 88(4):728-735 (2015). 2, Yao Y. et al. Neuropharmacol, 64:37-44 (2013). 3, Dang P M-C. et al. J Immunol, 166(2):1206-1213 (2001) |
| Molecular Weight | 1928.5 |
| Myr-SIYRRGARRWRKL | |
| Sequence(Three-Letter Code) | Myr - Ser - Ile - Tyr - Arg - Arg - Gly - Ala - Arg - Arg - Trp - Arg - Lys - Leu - OH |
| Product Citations | Bogard, A. S. et al. (2015). Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation. Mol Pharmcol doi: 10.1124/mol.115.099457. Deng, Z. et al. (2015). Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach. Neurobiol Learning Memory 118, 89.Kim, JV. et al. (2015). Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci 35, 6307. doi: 10.1523/JNEUROSCI.3481-14.2015.Lu, R. et al. (2015). PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell, mbc-E14. doi: 10.1091/mbc.E14-12-1613 Tillu, DV. et al. (2015). Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state Short Title: PAR2 activation causes chronic pain. Pain doi: 10.1097/j.pain.0000000000000125.Li, Q. et al. (2014). Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms. Cereb Cortex 24, 353. doi: 10.1093/cercor/bhs315.Vélez-Hernández, ME. et al. (2013). Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. J Drug Alcohol Res 2, 235669. doi: 10.4303/jdar/235669.Yao, Y. et al. (2013). Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacol 64, 37.Pauli, WM. et al. (2012). Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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