Anaspec/角蛋白K18-C/5 mg/AS-60214-5
商品编号:
AS-60214-5
品牌:
Anaspec
市场价:
¥10880.00
美元价:
5440.00
产品分类:
诊断酶
公司分类:
Diagnostic_enzyme
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | Keratin K18 - CRPVSSAApSVYAGAC |
Size | 5 mg |
Catalog # | AS-60214-5 |
US$ | $544 |
Purity | % Peak Area By HPLC ≥ 95% |
This peptide corresponds to human keratin K18 amino acids 26-38, with an additional C-terminal cysteine. The sequence is identical to mouse K18 except that human K18 Val28 is replaced by alanine in the mouse sequence. Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in-vivo, in a cell-cycle- and phosphorylation-dependent manner. K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins and plays a role in keratin organization and distribution. | |
Detailed Information | Material Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Ref: Ku, NO. et al. EMBO J. 17, 1892 (1998). |
Molecular Weight | 1418.5 |
RPVSSAApSVYAGAC | |
Sequence(Three-Letter Code) | H - Arg - Pro - Val - Ser - Ser - Ala - Ala - pSer - Val - Tyr - Ala - Gly - Ala - Cys - OH |
Product Citations | Dayon, Löıc. et al. J. Mass. Spectrom. 41, 1484 (2006). |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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