Anaspec/TIP 39，结节漏斗神经肽/1 mg/AS-21687
市场价：
¥8620.00
美元价：
4310.00
产品分类：
纯化试剂盒
公司分类：
Purification_kit
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | TIP 39, Tuberoinfundibular NeuropeptideSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP |
| Size | 1 mg |
| Catalog # | AS-21687 |
| US$ | $431 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a tuberoinfundibular neuropeptide and parathyroid hormone 2(PTH 2)-receptor agonist from hypothalmus. Synthetic TIP39 activates human and rat PTH2 receptors. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Usdin, TB. et al. Nat. Am. 2, 941 (1999); Piserchio, A. et al. J. Biol. Chem. 275, 27284 (2000). |
| Molecular Weight | 4504.3 |
| SLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP | |
| Sequence(Three-Letter Code) | H - Ser - Leu - Ala - Leu - Ala - Asp - Asp - Ala - Ala - Phe - Arg - Glu - Arg - Ala - Arg - Leu - Leu - Ala - Ala - Leu - Glu - Arg - Arg - His - Trp - Leu - Asn - Ser - Tyr - Met - His - Lys - Leu - Leu - Val - Leu - Asp - Ala - Pro - OH |
| Product Citations | Panda, D. et al. (2009). TIP39/Parathyroid Hormone Type 2 Receptor Signaling is a Potent Inhibitor of Chondrocyte Proliferation and Differentiation. Am J Physiol Endocrinol Metab 10.Barker, T. H. et al.(2004). Thrombospondin-1-induced Focal Adhesion Disassembly in Fibroblasts Requires Thy-1 Surface Expression, Lipid Raft Integrity, and Src Activation. J Biol Chem279, 23510.Bisello, Alessandro. et al. (2004). Agonist-Specific Regulation of Parathyroid Hormone (PTH) Receptor Type 2 Activity: Structural and Functional Analysis of PTH- and Tuberoinfundibular Peptide (TIP) 39-Stimulated Desensitization and Internalization. Mol Endocrinology 18, 1486.Sugimura, Y. et al.(2003). Centrally Administered Tuberoinfundibular Peptide of 39 Residues Inhibits Arginine Vasopressin Release in Conscious Rats. Endocrinology144, 2791.Hoare, S. R. J. et al.(2001). Evaluating the Signal Transduction Mechanism of the Parathyroid Hormone 1 Receptor. J Biol Chem276, 7741.Piserchio, A. et al.(2000). Structure of Tuberoinfundibular Peptide of 39 Residues. J Biol Chem275, 27284.Hoare, S. R. J. et al.(2000). Molecular Determinants of Tuberoinfundibular Peptide of 39 Residues (TIP39) Selectivity for the Parathyroid Hormone-2 (PTH2) Receptor. J Biol Chem275, 27274. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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