Anaspec/MBP，MAPK底物，生物素化，磷酸化/1mg/AS-29877
市场价：
¥5080.00
美元价：
2540.00
产品分类：
通风橱
公司分类：
stink_cupboard
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | MBP, MAPK Substrate, Biotinylated, PhosphorylatedBiotin - APR - pT - PGGRR |
| Size | 1 mg |
| Catalog # | AS-29877 |
| US$ | $254 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is an N-terminally biotinylated peptide, with a phosphorylated Thr97. The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. APRTPGGRR is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. APRTPGGRR is the most efficient substrate for phosphorylation reaction by ERK and is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Sommer, F. et al. Int. J. Impot. Res. 14, 217 (2002); Lents, NH. et al. Ann. N. Y. Acad. Sci. 973, 265 (2002); Kameshita, I. et al. J. Biochem. (Tokyo) 122, 168 (1997). |
| Molecular Weight | 1273.4 |
| Biotin-APR-pT-PGGRR | |
| Sequence(Three-Letter Code) | Biotin - Ala - Pro - Arg - pThr - Pro - Gly - Gly - Arg - Arg - OH |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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