Anaspec/MOG（35-55），小鼠，大鼠/1mg/AS-60130-1-免疫在线蚂蚁淘旗下平台

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商品详细Anaspec/MOG（35-55），小鼠，大鼠/1mg/AS-60130-1

Anaspec/MOG（35-55），小鼠，大鼠/1mg/AS-60130-1

商品编号： AS-60130-1

品牌： Anaspec

市场价： ¥2940.00

美元价： 1470.00

产地：美国(厂家直采)

公司：

产品分类：微球标准品

公司分类： microsph

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description

Sequence(One-Letter Code)

Product Name	MOG (35 - 55), mouse, ratMEVGWYRSPFSRVVHLYRNGK
Size	1 mg
Catalog #	AS-60130-1
US$	$147
Purity	% Peak Area By HPLC ≥ 95%
Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (1-3).MOG (35-55) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination (1-2).Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats (1-4). Every lot of MOG (35-55) peptide is tested and proven to induce EAE. For the EAE results of the current lot, please email biology@anaspec.com.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	1. Slavin, A. et al. Autoimmunity 28, 109 (1998). 2. Ichikawa, M. et al. Cellular Immunol 191, 97 (1999). 3. Kennel De March, A. et al. J Neuroimmunol 135, 117 (2003). 4. Robinson, W. et al. Nat Biotech 21, 1033 (2003).
Molecular Weight	2582
MEVGWYRSPFSRVVHLYRNGK
Sequence(Three-Letter Code)	H - Met - Glu - Val - Gly - Trp - Tyr - Arg - Ser - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - Lys - OH
Product Citations	Choi BY. et al.(2016) 2"-5" oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model. Neurosci Lett.;628:78-84. doi: 10.1016/j.neulet.2016.06.026.Mazzon C, et al. (2016) CCRL2 regulates M1/M2 polarization during EAE recovery phase. J Leukoc Biol. 2016 Jun;99(6):1027-33. doi: 10.1189/jlb.3MA0915-444RR.Chandraratna RA, et al. (2016) Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis. Am J Transl Res. 15;8(2):1016-26.Etesam Z, et al. (2016).Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis. J Mol Neurosci;60(1):94-101. doi: 10.1007/s12031-016-0789-5.Trubiani O, et al. (2016) Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res Ther 4;7:1. doi: 10.1186/s13287-015-0253-4.Choi BY et al. (2016) Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model. Neurobiol Dis;94:205-12. doi: 10.1016/j.nbd.2016.06.018. Miller, P. G. et al (2015). Transmembrane TNFTNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression. J Immunol 195 2633 doi: 10.4049/jimmunol.1500286. Maddell, A. et al. (2015). NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice Intl immunol doi: 10.1093/intimm/dxu147. Lacroix, S. et al. (2014). Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions PLoS One doi: 10.1371/journal.pone.0085916.Boullerne, A. et al. (2014). Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis J neurochem doi: 10.1111/jnc.12664.Ooi, J. H. et al. (2014). Dominant effects of the diet on the microbiome and the local and systemic immune response in mice PLoS One doi: 10.1371/journal.pone.0086366. Barkauskas, DS. et al. (2015). Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Exp Neurol doi:10.1016/j.expneurol.2015.02.018.Aubé, B. et al. (2014). Neutrophils Mediate BloodSpinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases. J Immunoldoi: 10.4049/jimmunol.1400401.Cantor, JM. (2014). CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis. J Neuroimmunol doi: 10.1016/j.jneuroim.2014.06.015.Krementsov, DN., et al. (2014). Sex‐specific control of central nervous system autoimmunity by p38 mitogen‐activated protein kinase signaling in myeloid cells. Ann Neurol 75, 50. doi: 10.1002/ana.24020.Nagashima, H. et al. (2014). The adaptor TRAF5 limits the differentiation of inflammatory CD4+ T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol 15, 449.Ouyang, S. et al. (2014). Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling. Brain Behav Immun 40, 61.Zhao, YG. et al. (2012). Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway. J Immunol, 189, 4417. doi: 10.4049/jimmunol.1200919.Polak, P. et al. (2011). Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 10.1093/brain/awq362. doi: 10.1093/brain/awq362.Shohreh, R. et al. (2011). GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis. Endocrinology 10.1210/en.2011-1317. doi: 10.1210/en.2011-1317.Aizman, E. et al. (2010). The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. J Neuroimmunol 229, 192. doi: 10.1016/j.jneuroim.2010.08.022.Simonini, MV. et al. (2010). Increasing CNS noradrenaline reduces EAE severity. J Neuroimmune Pharmacol 5, 252. doi: 10.1007/s11481-009-9182-2. Simonini, M. et al. (2010). Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins. ASN Neuro 10.1042/AN20090033.Toscano, MG. et al. (2010). Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs. Mol Ther 18, 1035. doi: 10.1038/mt.2009.293.Kawasaki, T. et al. (2009). A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun 385, 49. doi: 10.1016/j.bbrc.2009.05.020. Li, Q. et al. (2009). Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis. Mol Immunol 46, 2885. doi: 10.1016/j.molimm.2009.07.003.Li, Q. et al. (2009). The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis. Am J Pathol 175, 661. doi: 10.2353/ajpath.2009.081093.Guo, B. et al. (2008). The type 1 IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 118, 1680. doi: 10.1172/JCI33342.Sharp, AJ. et al. (2008). P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis. J Neuroinflammation 10.1186/1742-2094-5-33. doi: 10.1186/1742-2094-5-33.Frausto, RF. et al. (2007). Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. J Neuroimmunol 192, 124.

品牌介绍

Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。

公司介绍

品牌分类

Assay Kits Fluorescent Dyes 肽 n. 氨基酸( amino acid的名词复数 );氨基酸类;

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