Anaspec/SHLP6(类人小肽6)/1mg/AS-65591
市场价:
¥5920.00
美元价:
2960.00
产品分类:
其它成像系统
公司分类:
Other_imaging
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | SHLP6 (Small humanin - like peptide 6)H - MLDQDIPMVQPLLKVRLFND - OH |
Size | 1 mg |
Catalog # | AS-65591 |
US$ | $296 |
Purity | % Peak Area By HPLC ≥ 95% |
Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2All of these peptides are released into cytosol from mitochondria. SHLP6 has been shown to increase apoptosis with potential cancer targeting roles and also may be involved in aging.1-2 | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | -20°C |
References | 1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016). 2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017). . |
Molecular Weight | 2385.9 |
H-MLDQDIPMVQPLLKVRLFND-OH | |
Sequence(Three-Letter Code) | NH2 - Met - Leu - Asp - Gln - Asp - Ile - Pro - Met - Val - Gln - Pro - Leu - Leu - Lys - Val - Arg - Leu - Phe - Asn - Asp - COOH |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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