阿纳斯佩克/美兰-A,MART 1(26-35)/1毫克/AS-61011
市场价:
¥1260.00
美元价:
630.00
产品分类:
电泳缓冲液
公司分类:
Electrophoretic_buffer
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | Melan - A, MART 1 (26 - 35)EAAGIGILTV |
Size | 1 mg |
Catalog # | AS-61011 |
US$ | $63 |
Purity | % Peak Area By HPLC ≥ 95% |
This native Melan-A (26-35) decapeptide is an immunodominant antigen from melanocyte/melanoma (Melan-A/MART) protein that is more efficiently recognized by tumor-infiltrating lymphocytes (TILs) of melanoma patients than the Melan-A (27-35), but has lower binding affinity and stability than the ELAGIGILTV analog. | |
Detailed Information | Material Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Ref: Pinilla, C. et al. Cancer Res. 61, 5153 (2001). |
Molecular Weight | 943.5 |
EAAGIGILTV | |
Sequence(Three-Letter Code) | H - Glu - Ala - Ala - Gly - Ile - Gly - Ile - Leu - Thr - Val - OH |
Product Citations | Webb, J. et al (2010) Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (αE/β7 Integrin) in high-grade serous ovarian cancer Gynecologic Oncology 18, 228. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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