Anaspec/Ghrelin，大鼠，小鼠/5 mg/AS-24160
市场价：
¥19940.00
美元价：
9970.00
产品分类：
数字PCR系统
公司分类：
Digital_PCR_system
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Ghrelin, rat, mouseGS - S(n - octanoyl) - FLSPEHQKAQQRKESKKPPAKLQPR |
| Size | 5 mg |
| Catalog # | AS-24160 |
| US$ | $997 |
| Purity | % Peak Area By HPLC ≥ 95% |
Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human.Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Kojima, M. et al. Nature 402, 656 (1999), doi:10.1038/45230Yang J., et. al. Cell 132, 387 (2008).doi: 10.1016/j.cell.2008.01.017 Kojima, M. et. al. Physiol Rev 85, 495 (2005), doi: 10.1152/physrev.00012.2004 Perello, M. & Dickson, SL. J Neuroendocrinol 27, 424 (2015), doi: 10.1111/jne.12236 |
| Molecular Weight | 3314.8 |
| GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR | |
| Sequence(Three-Letter Code) | H - Gly - Ser - [Ser(n - octanoyl)] - Phe - Leu - Ser - Pro - Glu - His - Gln - Lys - Ala - Gln - Gln - Arg - Lys - Glu - Ser - Lys - Lys - Pro - Pro - Ala - Lys - Leu - Gln - Pro - Arg - OH |
| Product Citations | Ozfiliz, N. et al. (2011). Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs. Revue Med Vet 162, 65.Guneli, E. et a. (2010). Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats. Neurosci Lett 479, 226.Granado, M. et al. (2009). Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. Mol Cell Endocrinol 309, 67.Xu, J. et al. (2009). Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453, 58.Waseem, T. et al. (2008). Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143, 334. Yang, J. et al. (2008). Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387.Barazzoni, R. et al. (2007). Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats. Obesity 15, 2614.Liu, Y. et al. (2006). Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol 49, 244.Barazzoni, R. et al. (2004). Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. AJP-Endo Metab 288, E228. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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