Anaspec/HCV(丙型肝炎病毒)NS3/4A蛋白酶底物/1 mg/AS-60798
市场价:
¥14660.00
美元价:
7330.00
产品分类:
抗仓鼠
公司分类:
Anti_Armenian_Hamster
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | HCV (Hepatitis C Virus) NS3/4A Protease SubstrateAc - DE - Dap(QXL® 520) - EE - Abu - ψ - [COO]AS - C(5 - FAMsp) - NH2 |
Size | 1 mg |
Catalog # | AS-60798 |
US$ | $733 |
Purity | % Peak Area By HPLC ≥ 95% |
A highly sensitive FRET substrate for assaying HCV (Hepatitis C Virus) NS3/4A protease activity. It detects < 0.1pmol of HCV NS3/4A protease. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 490/512 nm. | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS)Poster |
Storage | -20°C |
References | Ref: Tong, XH. et al. Understanding Biology Using Peptides. Sylvie E. Blondelle(Editor): American Peptide Society(2005); Tang, Y. et al. Viral Hepatitis Meeting Abstract (2005). |
Molecular Weight | 1913.8 |
Ac-DE-Dap(QXL®520)-EE-Abu-ψ-[COO]AS-C(5-FAMsp)-NH2 | |
Sequence(Three-Letter Code) | Ac - Asp - Glu - Dap(QXL®520) - Glu - Glu - Abu - ψ - [COO] - Ala- Ser - Cys(5 - FAMsp) - NH2 |
Product Citations | Yu, X. et al. (2012). Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay. Antimicrob Agents Chemother, 56, 6109.Yu, X. et al. (2009). Development of a cell-based hepatitis C virus (HCV) infection FRET assay for high throughput antiviral compound screening. Antimicrob Agents Chemo doi:10.1128/AAC.00495-09.Seiwert, S. et al. (2008). Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227). Antimicrob Agents Chemother 52, 4432. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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