Anaspec/Cyclo ( - RGDfK)/1 mg/AS-61111
市场价：
¥1920.00
美元价：
960.00
产品分类：
其它天然蛋白
公司分类：
Other_natural_proteins
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Cyclo ( - RGDfK)Cyclo( - RGDfK) |
| Size | 1 mg |
| Catalog # | AS-61111 |
| US$ | $96 |
| Purity | % Peak Area By HPLC ≥ 95% |
In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Van Hagen, PM. et al. Int. J. Cancer 90, 186 (2000); Hu, B. et al. Biochem. 39, 2284 (2000). |
| Molecular Weight | 603.7 |
| Cyclo(-RGDfK) | |
| Sequence(Three-Letter Code) | Cyclo( - Arg - Gly - Asp - D - Phe - Lys) |
| Product Citations | Guan, F. et al. (2011). Sequence elucidation of an unknown cyclic peptide of high doping potential by ETD and CID tandem mass spectrometry. J Am Soc Mass Spectrom 22, 718.Paletta, J. et al. (2010). RGD-functionalisation of PLLA nanofibers by surface coupling using plasma treatment: influence on stem cell differentiation. J Mater Sci: Mater in Med 21, 1363.Xiong, X. et al. (2010). The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin. Biomater 31, 757.Zako, T. et al. (2009). Cyclic RGD peptide-labeled upconversion nanophosphors for tumor cell-targeted imaging. Biochem Biophys Res Commun 381, 54.Borgman, M. et al. (2008). Tumor-targeted HPMA copolymer-(RGDfK)-(CHX-A″-DTPA) conjugates show increased kidney accumulation. J Controlled Release 132, 193. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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