Anaspec/Cyclo（-GRGDSP）/5 mg/AS-61110-5
商品编号：
AS-61110-5
品牌：
Anaspec
市场价：
¥4980.00
美元价：
2490.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Cyclo ( - GRGDSP)GRGDSP, N to C cyclized |
| Size | 5 mg |
| Catalog # | AS-61110-5 |
| US$ | $249 |
| Purity | % Peak Area By HPLC ≥ 95% |
This cyclic peptide is a potent vasodilator. It is more powerful than the linear GRGDSP (Cat# 22945, 22946) in changing the vascular tone of arterioles isolated from rat cremaster muscle. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Mogford, JE. et al. Circulation Res. 79, 821 (1996). |
| Molecular Weight | 569.6 |
| GRGDSP, N to C cyclized | |
| Sequence(Three-Letter Code) | Cyclo( - Gly - Arg - Gly - Asp - Ser - Pro) |
| Product Citations | Burch, ML. et al. (2013). Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells. J Biol Chem 288, 7410. doi: 10.1074/jbc.M112.400259.Mukhatyar, V. et al. (2011). Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. Biomaterials doi:10.1016/j.biomaterials.2011.02.015.Kirkpatrick, ND. et al. (2007). Live imagine of collagen remodeling during angiogenesis. AJP-Heart 292, H3198.Nadanaka, S. et al. (2001). Occurrence of oligosialic acids on integrin α5subunit and their involvement in cell adhesion to fibronectin. J Biol Chem 276, 33657. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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