阿纳斯佩克/gp91 ds-tat/1毫克/AS-63818
市场价：
¥2540.00
美元价：
1270.00
产品分类：
DNA修饰酶
公司分类：
DNA_modification_enzyme
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | gp91 ds - tatYGRKKRRQRRRCSTRIRRQL - NH2 |
| Size | 1 mg |
| Catalog # | AS-63818 |
| US$ | $127 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into all cells. It is used as a peptide inhibitor for NADPH oxidase assembly. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Park, L. J. Neuroscience 25, 1769 (2005); Park, L. et al. Proc. Natl. Acad. Sci. 105, 1347 (2008) |
| Molecular Weight | 2673.2 |
| YGRKKRRQRRRCSTRIRRQL-NH2 | |
| Sequence(Three-Letter Code) | H - Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Cys - Ser - Thr - Arg - Ile - Arg - Arg - Gln - Leu - NH2 |
| Product Citations | Viola, H. et al. (2013). L-type Ca2+ channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte. Am J Physiol Heart Circ Physiol 304, H767. doi: 10.1152/ajpheart.00700.2012.Andrikopoulos, P. et al. (2015). Endothelial angiogenesis and barrier function in response to thrombin requires Ca2+ influx through the Na+/Ca2+ exchanger J Biol Chem doi: 10.1074/jbc.M114.628156. He, Y. et al. (2011). Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate. ASN Neuro doi:10.1042/AN20100025.Riquelme, D. et al. (2011). High-Frequency field stimulation of primary neurons enhances ryanodine receptor-mediated Ca2+ release and generates hydrogen peroxide, which jointly stimulate NF-kB activity. Antioxid Redox Signaling 14 doi: 10.1089/ars.2010.3238. Xia, M. et al. (2009). Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2. JTH8 doi: 10.1111/j.1538-7836.2009.03683.x. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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