Anaspec/MCC(88-103)/1mg/AS-60204-1
商品编号:
AS-60204-1
品牌:
Anaspec
市场价:
¥2040.00
美元价:
1020.00
产品分类:
细胞研究
公司分类:
Cell_Research
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | MCC (88 - 103)ANERADLIAYLKQATK |
Size | 1 mg |
Catalog # | AS-60204-1 |
US$ | $102 |
Purity | % Peak Area By HPLC ≥ 95% |
This peptide is derived from the carboxyl terminus of moth MCC (88¡V103) and pigeon cytochrome c plays a major role in T-cell selection. MCC (88-103) can induce positive selection of TCR transgenic thymocytes | |
Detailed Information | Material Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Ref: Garcia, G. et al. J. Immunol. 166, 3151 (2001); Wang, R. et al. Proc. Natl. Acad. Sci. USA 95, 3804 (1998). |
Molecular Weight | 1805.1 |
ANERADLIAYLKQATK | |
Sequence(Three-Letter Code) | H - Ala - Asn - Glu - Arg - Ala - Asp - Leu - Ile - Ala - Tyr - Leu - Lys - Gln - Ala - Thr - Lys - OH |
Product Citations | Fazilleau, N. et al. (2009). The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nature Immunol 10, 375. doi:10.1038/ni.1704.Sojka, DK. et al. (2004). IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition. J Immunol 172, 6136. doi: 10.4049/jimmunol.172.10.6136. Malherbe, L. et al. (2004). Clonal selection of Helper T Cells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity. 21, 669. doi: http://dx.doi.org/10.1016/j.immuni.2004.09.008. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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