Anaspec/Tat-Beclin-1,加扰/1 mg/AS-65468
市场价:
¥4020.00
美元价:
2010.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | Tat - Beclin - 1, scrambledYGRKKRRQRRRGGVGNDFFINHETTGFATEW |
Size | 1 mg |
Catalog # | AS-65468 |
US$ | $201 |
Purity | % Peak Area By HPLC ≥ 95% |
Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that may trigger cellular adaptation, survival or cell death. When conjugated to the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control.RELATED PRODUCTS:Tat-Beclin-1, Cat# 65467Beclin-1, Cat# 65466 | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Shoji-Kawata, S. Nature 494, 201-209 (2013); Marquez, RT. Am J Cancer Res 2 (2), 214221 (2012). |
Molecular Weight | 3741.1 |
YGRKKRRQRRRGGVGNDFFINHETTGFATEW | |
Sequence(Three-Letter Code) | Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Gly - Gly - Val - Gly - Asn - His - Phe - Phe - Ile - Asn - His - Ser - Thr - Thr - Gly - Phe - Ala - Thr - Gln - Trp - OH |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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