Anaspec/TAT（47-57）/1mg/AS-60023-1
商品编号：
AS-60023-1
品牌：
Anaspec
市场价：
¥1920.00
美元价：
960.00
产品分类：
信号通路
公司分类：
Signal_pathway
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | TAT (47 - 57)YGRKKRRQRRR |
| Size | 1 mg |
| Catalog # | AS-60023-1 |
| US$ | $96 |
This is the most characterized fragment of the HIV transactivator protein (TAT). This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Wang, H. et al. J. Clin. Invest. 109, 1463 (2002); Ziegler et al. Biochem. 44, 138 (2005); Wender, PA. et al. Proc. Natl. Acad. Sci. USA 97, 13003 (2000). |
| Molecular Weight | 1559.9 |
| YGRKKRRQRRR | |
| Sequence(Three-Letter Code) | H - Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - OH |
| Product Citations | Bartz, R. et al. (2011). Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape. Biochem J 10.1042/BJ20101021.Wang, G. et al. (2010). Resolving rotational motions of nano-objects in engineered environments and live cells with gold nanorods and differential interference contrast microscopy. J Am Chem Soc 132, 16417.Chothe, P. et al. (2009). Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Opthalmol Visual Sci 51, 413.Sun, W. et al. (2009). Wavelength-dependent differential interference contrast microscopy: selectively imaging nanoparticle probes in live cell. Anal Chem 81, 9203.Jain, M. et al. (2005). Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors 65, 7840.Matsushita, K. et al. (2005). A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol 67, 1137. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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