安乃近/Buforin/1毫克/AS-61255
市场价：
¥3620.00
美元价：
1810.00
产品分类：
DNA提取纯化试剂
公司分类：
DNA_extraction
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | BuforinTRSSRAGLQFPVGRVHRLLRK |
| Size | 1 mg |
| Catalog # | AS-61255 |
| US$ | $181 |
This peptide, also referred to as Buforin II peptide is a 21 amino acid peptide derived from Buforin I peptide that is isolated from the Asian toad Bufo gargarizans. The 21 amino acid peptide has been shown to possess anti-microbial activity by penetrating bacteria and inhibiting cellular functions. In comparison to magainin 2, this peptide binds DNA and RNA from E.coli with a much greater affinity. It is also considered a cell-delivery peptide and has been shown to deliver SiRNAs into cells followed by effective mRNA degradation. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Lan Y. et al. Biochim et Biophys Acta. 1798:1934-1943 (2010) 2, Bartz, R. et al. Biochem J. 435(2):475-487 (2011). |
| Molecular Weight | 2434.9 |
| TRSSRAGLQFPVGRVHRLLRK | |
| Sequence(Three-Letter Code) | Thr - Arg - Ser - Ser - Arg - Ala - Gly - Leu - Gln - Phe - Pro - Val - Gly - Arg - Val - His - Arg - Leu - Leu - Arg - Lys |
| Product Citations | Bartz, R. et al. (2011). Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape. Biochem J4352, 475-487. doi: 10.1042/BJ20101021. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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