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Anaspec/Protease - Activated Receptor - 4, PAR - 4 Agonist, amide/1 mg/AS-60218-1
Anaspec/Protease - Activated Receptor - 4, PAR - 4 Agonist, amide/1 mg/AS-60218-1
商品编号：
AS-60218-1
品牌：
Anaspec
市场价：
¥1360.00
美元价：
680.00
产品分类：
电源
公司分类：
power_pack
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Protease - Activated Receptor - 4, PAR - 4 Agonist, amideAYPGKF - NH2 |
| Size | 1 mg |
| Catalog # | AS-60218-1 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005). |
| Molecular Weight | 680.8 |
| AYPGKF-NH2 | |
| Sequence(Three-Letter Code) | H - Ala - Tyr - Pro - Gly - Lys - Phe - NH2 |
| Product Citations | Naik, M.U. et al. (2009). CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3 J Thrombosis Haemostasis 7 doi: 10.1111/j.1538-7836.2009.03581.x.Lindsey, S. et al. (2014). Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling J Thrombosis Haemostasis 12 doi: 10.1111/jth.12490. Naik, M. U. et al. (2012). JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets blood119 doi: 10.1182/blood-2011-12-397398. Patil, S.B. et al. (2010). Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima Am Heart Assoc doi: 10.1161/ATVBAHA.110.210732.Panicot-Dubois, L. et al. (2007). Bile saltdependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans J Clinical Invest doi:10.1172/JCI32655. Erhard, J.A. et al. (2006). P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation J Thrombosis Haemostasis4 doi: 10.1111/j.1538-7836.2006.01849.x. Rauch, B. H. et al. (2003) Thrombin- and factor Xainduced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells Am Heart Assoc doi: 10.1161/01.RES.0000111805.09592.D8. Murad, JP. et al. (2012). Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan J Cardiovasc Pharmacol Ther 17 308. doi: 10.1177/1074248411425491.Su, X. et al.(2005) Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1J Immunol 175 doi: 10.4049/jimmunol.175.4.2598.Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells Blood 102 doi: 10.1182/blood-2003-04-1130. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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