AANPEC/蛋白酶激活受体3，PAR 3激动剂，酰胺/ 1 mg/AS-629 38
市场价：
¥1360.00
美元价：
680.00
产品分类：
其它酶
公司分类：
Other_enzymes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Protease - Activated Receptor - 3, PAR - 3 Agonist, amideSFNGGP - NH2 |
| Size | 1 mg |
| Catalog # | AS-62938 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is one of the four PAR sub-types, and is acted upon by thrombin; not trypsin. It is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. PARs have been studied for their roles in itch and, their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR4. Co-expression of PAR3 and PAR4enhances thrombin action suggesting that PAR3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR4. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008). 2, Leger, AJ. et al. Circ, 114:1070-1077 (2006). |
| Molecular Weight | 576.6 |
| SFNGGP-NH2 | |
| Sequence(Three-Letter Code) | H - Ser - Phe - Asn - Gly - Gly - Pro - NH2 |
| Product Citations | Keiichi, I. et al. (2014). Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; the experiment by neonatal rat atrial fibroblasts. IJC Heart & Vess 2:21-23. doi: 10.1016/j.ijchv.2013.11.005 Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart. Circ. Physiol 296, L979. doi: 10.1152/ajplung.90412.2008.Rauch, BH. et al. (2004). Thrombin- and Factor Xainduced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res 94, 340. doi: 10.1161/01.RES.0000111805.09592.D8 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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