AANPEC/蛋白酶激活受体1，PAR 1激动剂，酰胺/ 1毫克/ AS-629 36
市场价：
¥1360.00
美元价：
680.00
产品分类：
纯水机
公司分类：
water_purifier
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Protease - Activated Receptor - 1, PAR - 1 Agonist, amideTFLLRNPNDK - NH2 |
| Size | 1 mg |
| Catalog # | AS-62936 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the "tethered ligand" that thrombin makes available through proteolytic cleavage of substrate.It is also known to cause increase in liquid and protein permeability much like thrombin. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Vogel, SM. et al. Physiol. Genom. 4:137-145 (2000). |
| Molecular Weight | 1216.4 |
| TFLLRNPNDK-NH2 | |
| Sequence(Three-Letter Code) | H - Thr - Phe - Leu - Leu - Arg - Asn - Pro - Asn - Asp - Lys - NH2 |
| Product Citations | Kouzaki, H. et al. (2013). Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells J. Resp. Cell. Mol. Biol49(5):741-750. doi:10.1165/rcmb.2012-0304OCMosnier, L. O. (2012). Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood doi: http://dx.doi.org/10.1182/blood-2012-08-452169. Wang, W. et al. (2009). Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. Int J Cancer126, 599. doi: 10.1002/ijc.24904. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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