AANPEC/蛋白酶激活受体1，PAR 1激动剂/ 1 mg/AS-61530
市场价：
¥1260.00
美元价：
630.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Protease - Activated Receptor - 1, PAR - 1 AgonistTFLLRN |
| Size | 1 mg |
| Catalog # | AS-61530 |
| US$ | $63 |
| Purity | % Peak Area By HPLC ≥ 95% |
This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Syeda,, F. et al. J. Biol. Chem281, 11792 (2006); Jenkins, R. et al. J. Clin. Invest; 116, 1606 (2006). |
| Molecular Weight | 762.9 |
| TFLLRN | |
| Sequence(Three-Letter Code) | H - Thr - Phe - Leu - Leu - Arg - Asn - OH |
| Product Citations | Mogami, H. et al. (2014). Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289, 13295. doi: 10.1074/jbc.M114.550541.Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 296, L979.Wilson, TJ. et al. (2009). Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.Cancer Res. 69, 3188.Jenkins, RG. et al. (2006). Ligation of protease-activated receptor 1 enhances αv β6 integrindependent TGF-β activation and promotes acute lung injury J. Clin. Invest. 116, 1606.Rauch, BH. et al.(2004). Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res. 94, 340. Kataoka, H. et al.(2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood102, 3224. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
联络我们
