Anaspec/LSKL, Inhibitor of Thrombospondin (TSP - 1)/1 mg/AS-60877
市场价：
¥1360.00
美元价：
680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | LSKL, Inhibitor of Thrombospondin (TSP - 1)LSKL - NH2 |
| Size | 1 mg |
| Catalog # | AS-60877 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß; thus preventing the progression of hepatic damage and fibrosis. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Ribeiro, SM. et al. J. Biol. Chem. 274, 13586 (1999); Kondou, H. et al. J. Hepatol. 39, 742 ( 2003). |
| Molecular Weight | 458.6 |
| LSKL-NH2 | |
| Sequence(Three-Letter Code) | H - Leu - Ser - Lys - Leu - NH2 |
| Product Citations | Pallero, M.A. et al. (2010). Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-Beta activation by vascular smooth muscle cells: implications for in-stent restenosis Vasc Res47 doi: 10.1159/000265565. Wang, S. et al. (2010). Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells. Am J Physiol Cell Physiol doi:10.1152/ajpcell.00330.2009.Xie, X. et al. (2010). LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction. Archives Pharmac Res33 doi: 10.1007/s12272-010-0213-6. Belmadani, S. et al. (2007). A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Patholdoi:10.2353/ajpath.2007.070056.Zhou, Y. et al. (2004). Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli Am J Pathol165 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
联络我们
