Anaspec/Endothelin 1, human, porcine/0.25 mg/AS-22859
市场价：
¥3720.00
美元价：
1860.00
产品分类：
血清纯化蛋白
公司分类：
Serum_purified_protein
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Endothelin 1, human, porcineCSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1 - 15 and 3 - 11) |
| Size | 0.25 mg |
| Catalog # | AS-22859 |
| US$ | $186 |
| Purity | % Peak Area By HPLC ≥ 95% |
ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988). |
| Molecular Weight | 2492 |
| CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11) | |
| Sequence(Three-Letter Code) | H - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11) |
| Product Citations | Ansar, S. et al. (2009). Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. J Neurosurg 111, 5.Wang, Y. et al. Brain Res. 1167, 118 (2007).Cervar-Zivkovic, M. et al. Reprod. Sci. 14, 430 (2007).Beg, SAS. et al. J. Cer. Blood Flow Metab. 26, 846 (2006).Ansar, S. et al. J. Neurosurgery 106, DOI: 10.3171/jns.2007.106.5.881 (2006). |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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