![Anaspec/[Trp63，64]-C3a（63-77）/1mg/AS-61119](https://www.ebiomall.cn/images/Anaspec/icon_msds.gif){kind=icon}
Anaspec/[Trp63，64]-C3a（63-77）/1mg/AS-61119
市场价：
¥2160.00
美元价：
1080.00
产品分类：
烘片机
公司分类：
Film_drying_machine
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | [Trp63, 64] - C3a (63 - 77)WWGKKYRASKLGLAR |
| Size | 1 mg |
| Catalog # | AS-61119 |
| US$ | $108 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide, which is a C-terminal analogue of the complement factor C3a, acts as an agonist to the C3a receptor. It is derived from the fifteen C-terminal residues (6-77) of C3a. In in vitro studies, both C 3a and this peptide have been shown to selectively bind to C3aRs and induce degranulation of C3aR-transfeted RBL-2H3 cells. There was also a rapid, transient and concentration-dependent hypertensive response observed in rats when infused intravenously with C3a and this peptide. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Proctor LM et al. Intl Immunopharmacol. 9, 800-806 (2009). 2, Ames, R. et al. Immunopharmacol. 38, 87 (1997). |
| Molecular Weight | 1820.2 |
| WWGKKYRASKLGLAR | |
| Sequence(Three-Letter Code) | H - Trp - Trp - Gly - Lys - Lys - Tyr - Arg - Ala - Ser - Lys - Leu - Gly - Leu - Ala - Arg - OH |
| Product Citations | Russell, J. et al. (2011). Parallel detection of intrinsic fluorescence from peptides and proteins for quantification during mass spectrometric analysis Anal Chem 83 (6) 21872193. doi: 10.1021/ac103023q. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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