Anaspec/Caspase 3（Apopain）底物1r-z，荧光/5 mg/AS-60304-5
商品编号：
AS-60304-5
品牌：
Anaspec
市场价：
¥7220.00
美元价：
3610.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Caspase 3 (Apopain) Substrate 1r - z, fluorogenic(Z - DEVD)2 - Rh110 |
| Size | 5 mg |
| Catalog # | AS-60304-5 |
| US$ | $361 |
Rh110 (rhodamine 110)-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. Cleavage of Rh110 peptides by caspases generates strongly fluorescent Rh110 that is monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments. Caspase-3 substrate and caspase-7 substrate | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C desiccated and protected from light |
| References | Gurtu V, et al. (1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 251, 98-102; Martins LM, et al. (1997). Activation of multiple interleukin-1 ? converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272, 7421-30. |
| Molecular Weight | 1515.5 |
| (Z-DEVD)2-Rh110 | |
| Sequence(Three-Letter Code) | z - (Asp - Glu - Val - Asp)2 - Rh110 |
| Product Citations | Monian, P. et al. (2015). The cellular apoptosis susceptibility protein (CAS) promotes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis and cell proliferation J. Biol. Chem 291:2379 doi: 10.1074/jbc.M115.685008 Sanchez-Gonzalez, PD. et al. (2011). Effects of deferasirox on renal function and renal epithelial cell death. Toxicol Lett 203 154. doi:10.1016/j.toxlet.2011.03.018 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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