Anaspec/PMAP-23/1 mg/AS-65596
市场价:
¥4020.00
美元价:
2010.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Name | PMAP - 23NEWRIIDLLWRVRRPQKPKFVTVWVR |
Size | 1 mg |
Catalog # | AS-65596 |
US$ | $201 |
Purity | ≥95% |
Porcine myeloid antimicrobial peptide-23 (PMAP-23) is a host defense peptide that belongs to cathelicidins. It has potent activity against Gram-negative and Gram-positive bacteria1, and displays strong antifungal activity against yeast and mold2-3. It is not toxic to eukaryotic cells up to concentrations 100 times higher than those needed for bactericidal activity. | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | 20°C |
References | 1.Park K et al., Biochem. Biophys. Res. Commun. 290(1) 204-212 (2002) 2.Edwin J.A.V et al., Protein Pept Lett. 24(7),609-616 (2017)3. Lee D.G et al., Biochem. Biophys. Res. Commun ,282 (2) 570-74 (2001) |
Molecular Weight | 2962.77 |
RIIDLLWRVRRPQKPKFVTVWVR | |
Sequence(Three-Letter Code) | H - Arg - Ile - Ile - Asp - Leu - Leu - Trp - Arg - Val - Arg - Arg - Pro - Gln - Lys - Pro - Lys - Phe - Val - Thr -Val - Trp - Val - Arg - OH |
Solvent System | PMAP-23 antimicrobial peptide is freely soluble in H2O |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。
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