Anaspec/Magainin 1/0.5 mg/AS-20791
市场价：
¥2040.00
美元价：
1020.00
产品分类：
生化标准品
公司分类：
Biochemical_standard
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Magainin 1GIGKFLHSAGKFGKAFVGEIMKS |
| Size | 0.5 mg |
| Catalog # | AS-20791 |
| US$ | $102 |
| Purity | % Peak Area By HPLC ≥ 95% |
Magainins are peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis. Magainin 1 and 2 are closely related peptides of 23 amino acids each and differ by two substitutions. These antimicrobial peptides have broad-spectrum, non-specific activity against a wide range of micro-organisms, including viruses, gram-positive and gram-negative bacteria, protozoa, yeasts and fungi, and may also be hemolytic and cytotoxic to cancer cells. Magainin 1 is a bactericide. Both Magainin 1 and 2 exhibit inhibitory action toward Herpes simplex virus type 1(HSV-1) and HSV-2. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Williams, RW. et al. Biophysical J. 53, 631A (1988); Morvan, A. et al. Mol. Mar. Biol. Biotechnol. 3, 327 (1994); Matanic, A. et al. Int. J. Antimicrob. Agents 23, 382 (2004); Zasloff, M. Proc. Natl. Acad. Sci. 84, 5449 (1987). |
| Molecular Weight | 2409.9 |
| GIGKFLHSAGKFGKAFVGEIMKS | |
| Sequence(Three-Letter Code) | H - Gly - Ile - Gly - Lys - Phe - Leu - His - Ser - Ala - Gly - Lys - Phe - Gly - Lys - Ala - Phe - Val - Gly - Glu - Ile - Met - Lys - Ser - OH |
| Product Citations | Dixon, DR. et al. (2009). Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide. Peptides 30, 2161.Leung, P. et al. (2009). Antimicrobial Peptides for Plaque Control. Advances in Dental Research 21, 57.Novik, V. et al. (2009). Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant. Infect Immun 77, 5428. doi: 10.1128/IAI.00528-09.Kulagina, NV. et al. (2007). Antimicrobial peptides as new recognition molecules for screening challenging species. Sens Actuators B Chem 121, 150.Kulagina, N. et al. (2005). Antimicrobial Peptides for Detection of Bacteria in Biosensor Assays. Anal Chem 77, 6504. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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