Anaspec/LL-37，抗菌肽，人/1 mg/AS-61302
市场价：
¥3760.00
美元价：
1880.00
产品分类：
抗过氧化物酶
公司分类：
Anti_Peroxidase
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | LL - 37, Antimicrobial Peptide, humanLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
| Size | 1 mg |
| Catalog # | AS-61302 |
| US$ | $188 |
| Purity | % Peak Area By HPLC ≥ 95% |
Antimicrobial peptide LL-37, belongs to the cathelicidin family of peptides, and this peptide corresponds to the sequence of the first amphipathic alpha-helical peptide isolated from human. It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells , LL-37 is significantly resistant to proteolytic degradation in solution. more Antimicrobial peptides | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Dürr, UHN. et al. Biochim. Biophys. Acta 1758, 1408 (2006); Neville, F. et al. Biophys. J. 90, 1275 (2006); Oren, Z. et al. Biochem. J. 341, 501(1999). |
| Molecular Weight | 4493.3 |
| LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | |
| Sequence(Three-Letter Code) | H - Leu - Leu - Gly - Asp - Phe - Phe - Arg - Lys - Ser - Lys - Glu - Lys - Ile - Gly - Lys - Glu - Phe - Lys - Arg - Ile - Val - Gln - Arg - Ile - Lys - Asp - Phe - Leu - Arg - Asn - Leu - Val - Pro - Arg - Thr - Glu - Ser - OH |
| Product Citations | Hou, S. et al. (2015). Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37 ASM 83 doi: 10.1128/IAI.00746-15Xiong, M. (2015). Helical antimicrobial polypeptides with radial amphiphilicity pnas doi: 10.1073/pnas.1507893112.Cullen, TW. et al. (2013). EptC of Campylobacter jejuni mediates phenotypes involved in host interactions and virulence Infect Immun 81 430. doi: 10.1128/IAI.01046-12.Henningham, A. et al. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio 4, e00509 Moffatt, JH. et al. (2013). Lipopolysaccharide-Deficient Acinetobacter baumannii Shows Altered Signaling through Host Toll-Like Receptors and Increased Susceptibility to the Host Antimicrobial Peptide LL-37. Infect Immun 81, 684 Okumura, CYM. et al. (2013). Use of a real-time polymerase chain reaction thermocycler to study bacterial cell permeabilization by antimicrobial peptides. mBio 4, e00499 Stover, E. et al. (2013). Screening Antimicrobial Peptides In Vitro for Use in Developing Transgenic Citrus Resistant to Huanglongbing and Citrus Canker. J Amer Soc Hort Sci 138. 142 Taneja, NK. et al.(2013). d-Alanine Modification of a Protease-Susceptible Outer Membrane Component by the Bordetella pertussis dra Locus Promotes Resistance to Antimicrobial Peptides and Polymorphonuclear Leukocyte-Mediated Killing. J Bacteriol 195, 5102Gilmore, SA. et al. (2012). Sulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages. ACS Chem Biol 7, 863. doi: 10.1021/cb200311s Hocquellet, A. et al.(2012). Importance of the disulfide bridges in the antibacterial activity of human hepcidin. Peptides 36, 303Love, JF. et al. (2012). Vitamin D and the Human Antimicrobial Peptide LL-37 Enhance Group A Streptococcus Resistance to Killing by Human Cells. mBio 3 doi: 10.1128/mBio.00394-12 McQuade, R. et al.(2012). Clostridium difficile clinical isolates exhibit variable susceptibility and proteome alterations upon exposure to mammalian cationic antimicrobial peptides.Anaerobe 286, 18890. doi: 10.1074/jbc.M110.206110Richards, SM. et al. (2012). Cationic antimicrobial peptides serve as activation signals for the Salmonella Typhimurium PhoPQ and PmrAB regulons in vitro and in vivo.Front Cell Infect Microbiol 2, 102. doi: 10.3389/fcimb.2012.00102 Strandberg, KL. et al. (2012). Cathelicidin Antimicrobial Peptide Expression Is Not Induced or Required for Bacterial Clearance during Salmonella enterica Infection of Human Monocyte-Derived Macrophages. Infect Immun doi: 10.1128/IAI.00672-12 Sun, Y. et al. (2012). Fatty Acids Regulate Stress Resistance and Virulence Factor Production for Listeria monocytogenes. J Bacteriol 194, 5274. doi: 10.1128/JB.00045-12 Vega, LA. et al. (2012). Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal. Mol Microbiol 85, 1119. doi: 10.1111/j.1365-2958.2012.08163.x Wu, W. et al.(2012). The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation Leukemia 26, 736. doi: 10.1038/leu.2011.252Campbell, GR. and SA. Spector(2011). Hormonally Active Vitamin D3 (1α,25-Dihydroxycholecalciferol) Triggers Autophagy in Human Macrophages That Inhibits HIV-1 Infection JBC 286, 18890. doi: 10.1074/jbc.M110.206110 Dean, SN. et al. (2011). Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37.Front Microbiol 2, 128. doi: 10.3389/fmicb.2011.00128 Lebeer, S. et al.(2011). Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine Microbial Biotech 4, 368McBride, SM. et al. (2011).The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile. Microbiol 157, 1457. doi: 10.1099/mic.0.045997-0 Sakoulas, G. et al. (2011). Ampicillin Enhances Daptomycin- and Cationic Host Defense Peptide-Mediated Killing of Ampicillin- and Vancomycin-Resistant Enterococcus faecium.Antimicrob Agents Chemother 56, 838. doi: 10.1128/AAC.05551-11 Sochacki, KA. et al. (2011). Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37.PNAS 108, E77. doi: 10.1073/pnas.1101130108 Subramanian, H. et al. (2011). Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.JBC 286, 44739. doi: 10.1074/jbc.M111.277152 Amer, L. et al. (2010). Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against FrancisellaBBRC 396, 246 Cole, JN. et al. (2010). M Protein and Hyaluronic Acid Capsule Are Essential for In Vivo Selection of covRS Mutations Characteristic of Invasive Serotype M1T1 Group A Streptococcus.mBio 1 doi: 10.1128/mBio.00191-10 Gable, JE. et al. (2009). Fluorescence and UV Resonance Raman Study of Peptide−Vesicle Interactions of Human Cathelicidin LL-37 and Its F6W and F17W Mutants Biochem 48, 11264. doi: 10.1021/bi900996q Inomata, KA. et al. (2010). Suppressive effect of the antimicrobial peptide LL‐37 on expression of IL‐6, IL‐8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts Eur J Oral Sci 118, 574. doi: 10.1111/j.1600-0722.2010.00775.x Kanda, N. et al. (2010). Increased serum leucine, leucine-37 levels in psoriasis: Positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines Hum Immunol 71, 1161 Krasnodembskaya, A. et al. (2010). Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.Stem Cells doi: 10.1002/stem.544 Kooi, C & PA Sokol, (2009). Burkholderia cenocepacia zinc metalloproteases influence resistance to antimicrobial peptides.Microbiology 155, 2818 Yin, J & FS Yu, (2009). LL-37 via EGFR Transactivation to Promote High GlucoseAttenuated Epithelial Wound Healing in Organ-Cultured CorneasARVO 10.1167/iovs.09-3904 Purdy, GE. et al. (2009). Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides. Mol Microbiol 73, 844. doi: 10.1111/j.1365-2958.2009.06801.x Schlamadinger, DE. et al. (2009). Toxins and antimicrobial peptides: interactions with membranes SPIE Proceedings 7397 doi: 10.1117/12.827439 Lee, HM. et al. (2009). Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes Leukemia 23, 2052. doi:10.1038/leu.2009.158 Bourbon, C. et al. (2008). Use of a real-time polymerase chain reaction thermocycler to study bacterial cell permeabilization by antimicrobial peptides.Anal Biochem 381, 279 |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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