阿纳派克/吲哚青霉素/1 mg/AS-60999
市场价：
¥2940.00
美元价：
1470.00
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3392242852
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4000-520-616
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商品介绍
| Product Name | IndolicidinILPWKWPWWPWRR - NH2 |
| Size | 1 mg |
| Catalog # | AS-60999 |
| US$ | $147 |
| Purity | % Peak Area By HPLC ≥ 95% |
Indolicidin, a member of the cathelicidin protein family, is a 13-residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin is microbicidal in-vitro against gram-positive and gram-negative bacteria, fungi, protozoa, and human immunodeficiency virus (HIV-1). | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Ösapay, K. et al. J. Biol. Chem. 275, 12017 (2000); Ahmad, I. et al. Biochim. Biophys. Acta 1237, 109 (1995); Aley, SB. Infect. Immun. 62, 5397 (1994); Robinson, W. et al. J. Leukocyte Biol. 63, 94 (1998). |
| Molecular Weight | 1906.3 |
| ILPWKWPWWPWRR-NH2 | |
| Sequence(Three-Letter Code) | H - Ile - Leu - Pro - Trp - Lys - Trp - Pro - Trp - Trp - Pro - Trp - Arg - Arg - NH2 |
| Product Citations | Yu, G. et al. (2016). Combination effects of antimicrobial peptides Antimicrob Agents Chemother doi: 10.1128/AAC02434-15.Chung, M.C. et al. (2015). Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37 Biochem J doi: 10.1042/BJ20150432. Stover, E. et al. (2013). Screening antimicrobial peptides in vitro for use in developing transgenic citrus resistant to Huanglongbing and citrus canker. J Amer Soc Hort Sci138 Dixon, DR. et al. (2009). Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide. Peptides30 doi: 10.1016/j.peptides.2009.07.027. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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