Anaspec/血管紧张素II底物/1 mg/AS-24520
市场价：
¥4880.00
美元价：
2440.00
产品分类：
定量PCR
公司分类：
real_time_PCR
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Angiotensin II SubstrateDRV - pY - IHPF |
| Size | 1 mg |
| Catalog # | AS-24520 |
| US$ | $244 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991).2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993). |
| Molecular Weight | 1126.2 |
| DRV-pY-IHPF | |
| Sequence(Three-Letter Code) | H - Asp - Arg - Val - pTyr - Ile - His - Pro - Phe - OH |
| Product Citations | Crowe, MC. and Brodbelt, JS. (2004). Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides. J. Am. Soc. for Mass Spectrom 15, 1581. doi: 10.1016/j.jasms.2004.07.016.Woods, A. S. et al. J. (2003). Angiotensin IIAcetylcholine noncovalent complexes analyzed with MALDIIon mobilityTOF MS. Biomol. Tech 14, 1. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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